Aloe vera (Aloe barbadensis, Aloe capensis).

BACKGROUND: Aloe vera, a succulent plant prevalent in hot, dry regions of Asia, Africa, and other areas, has been used in traditional medicine for many centuries. It is easily propagated in most places where the climate is hot and dry. The gel and dried latex obtained from aloe leaves are used for relief of constipation; for wound healing; and for treatment of burns, psoriasis, frostbite, ulcerative colitis, and diabetes. Aloe is marketed via the Internet and in health food stores in juice, softgel, and capsule forms, and as an ingredient in topical creams. Despite lack of substantial evidence, aloe products are promoted to cancer patients, especially for use against radiation-induced skin toxicity. RESEARCH: In vitro studies indicate that aloe has immunomodulatory, anticancer,[1,2] antioxidant, and anti-inflammatory properties.[3] Emodin, an extract of aloe, inhibits cell proliferation and induces apoptosis in human liver cancer cell lines via p53and p21-dependent pathways.[4] One study showed topical aloe vera to be superior to silver sulfadiazine cream, an agent commonly used to treat second-degree burns.[5] A few trials have explored aloe’s anticancer effects. Concurrent oral administration of aloe with chemotherapy was reported to increase the efficacy of chemotherapy in patients with metastatic cancers[6] and to prevent oral mucositis.[7] Data on topical aloe’s role in alleviating radiation therapy-induced skin damage are inconsistent.[8,9] More research is needed to determine the safety and efficacy of aloe vera in cancer patients TAKE HOME POINTS